A Peripheral Blood Signature of Vasodilator - Responsive Pulmonary Arterial Hypertension Running title :

A Peripheral Blood Signature of Vasodilator - Responsive Pulmonary Arterial Hypertension

M Medicine, De e ep partme me ment o of f P P Pediat atri ric cs, , Vand nd nderbi i ilt t Un niv iv ver er ers sit t ty M M Me e edica a al C Ce Cen nt nte e er, , Na a ash h hvi ill le e, T TN N Abstract Background—Heterogeneity in response to treatment of pulmonary arterial hypertension (PAH)

Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.

BACKGROUND Heterogeneity in response to treatment of pulmonary arterial hypertension (PAH) is a major challenge to improving outcome in this disease. Although vasodilator-responsive PAH (VR-PAH) accounts for a minority of cases, VR-PAH has a pronounced response to calcium channel blockers and better survival than vasodilator-nonresponsive PAH (VN-PAH). We hypothesized that VR-PAH has a differen...

The effects of flosequinan on hemodynamics and oxygen delivery in cor pulmonale.

The hemodynamic effects of a new orally active vasodilator, flosequinan, were compared with placebo (single blind) over 24 h in eight patients with pulmonary hypertension secondary to severe chronic obstructive pulmonary disease. Mean pulmonary artery pressure was reduced by 5.1 (3.4, 6.7) mm Hg (mean 95 percent CI) (p < 0.003) and pulmonary vascular resistance was reduced by 70 (23, 189) dynes...

Vasodilator responsiveness in idiopathic pulmonary arterial hypertension: identifying a distinct phenotype with distinct physiology and distinct prognosis

Within the cohort of patients suffering from idiopathic pulmonary arterial hypertension (IPAH) is a group that responds dramatically (VR-PAH) to an acute vasodilator challenge and that has excellent long-term hemodynamic improvement and prognosis on high dose calcium channel blockers compared with vasodilator non-responders (VN-PAH). For the purposes of diagnosing VR-PAH, there is to date no te...

Prognostic Value of Blood Gas Analyses in Patients with Idiopathic Pulmonary Arterial Hypertension Running title: Blood gases in IPAH